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The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice

29 Oct 2018

Abstract excerpt

The pleiotropic interleukin-6 (IL-6)-type cytokine oncostatin M (OSM) signals in multiple cell types, affecting processes such as cell differentiation, hematopoiesis, and inflammation. In humans, OSM exerts its effects through activation of either of two different heterodimeric receptor complexes, formed by glycoprotein 130 (gp130) and either OSM receptor (OSMR) or leukemia inhibitory factor receptor (LIFR). In...

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PMID: 30373773
DOI: 10.1074/jbc.ra118.004375

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