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Article

STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jan 2025

Huang Shiyu, Qin Xuke, Fu Shujie, Hu Juncheng, Jiang Zhengyu, Hu Min, Zhang Banghua, Liu Jiachen, Chen Yujie, Wang Minghui, Liu Xiuheng, Chen Zhiyuan, Wang Lei

Abstract excerpt

Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial-to-mesenchymal transition (EMT) is associated with immune evasion and can contribute to immunotherapy resistance. Here, the involvement of STAM Binding Protein Like 1 (STAMBPL1) is reported in...

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Topics

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Share to Axl Receptor Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Epithelial-Mesenchymal Transition

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Source

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Identifiers

PMID: 39527690
DOI: 10.1002/advs.202405083
PMCID: PMC11714167

Genes

STAMBPL1
AXL
TRIM21
CXCL9
STAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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