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Article

GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling.

Journal of cellular and molecular medicine - 1 Apr 2024

Huang Shiyu, Liu Jiachen, Hu Juncheng, Hou Yanguang, Hu Min, Zhang Banghua, Luo Hongbo, Fu Shujie, Chen Yujie, Liu Xiuheng, Chen Zhiyuan, Wang Lei

Abstract excerpt

Growth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38588015
DOI: 10.1111/jcmm.18290
PMCID: PMC11000813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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