Article
KRAS mutations promote the intratumoral colonization of enterotoxigenic bacteroides fragilis in colorectal cancer through the regulation of the miRNA3655/SURF6/IRF7/IFNβ axis.
Gut microbes - 1 Jan 2024
Chen Yizhen, Liu Shaolin, Tan Song, Zheng Yuanyuan, Chen Yifan, Yang Changshun, Lin Shengtao, Mi Yulong, Li Weihua
Abstract excerpt
KRAS mutations are associated with poor prognosis in colorectal cancer (CRC). Although the association between the gut microbiota and CRC has been extensively documented, it is unclear whether KRAS mutations can regulate the gut microbiota. Metagenomics has identified changes in the diversity of the gut microbiota in CRC due to KRAS mutations. Specifically, KRAS mutations positively correlate with the abundance...
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