Article
Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model.
Microbiology spectrum - 2 May 2024
Huang Zigui, Huang Xiaoliang, Huang Yili, Liang Kunmei, Chen Lei, Zhong Chuzhuo, Chen Yingxin, Chen Chuanbin, Wang Zhen, He Fuhai, Qin Mingjian, Long Chenyan, Tang Binzhe, Huang Yongqi, Wu Yongzhi, Mo Xianwei, Weizhong Tang, Liu Jungang
Abstract excerpt
Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, the association between gut microbiota and KRAS mutation in CRC remains enigmatic. We conducted 16S rRNA sequencing on stool samples from 94 CRC patients and employed the linear discriminant analysis effect size algorithm to identify distinct gut microbiota between KRAS mutant and...
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