Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4.

Journal of cellular and molecular medicine - 1 Oct 2024

Chen Yizhen, Zheng Yuanyuan, Liu Shaolin

Abstract excerpt

This study explores and verifies potential molecular targets through which KRAS mutations regulate the colonization of Fusobacterium nucleatum (FN) in colorectal cancer (CRC). This study combined multiple bioinformatics methods and biological assays. Through The Cancer Genome Atlas, Gene Expression Omnibus, Human Protein Atlas, immunohistochemistry, and co-culture assays, we further confirmed the differential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Adhesion
Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Gene Expression Regulation, Neoplastic

Share to Mutation

Share to Prognosis

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 39462261
DOI: 10.1111/jcmm.70182
PMCID: PMC11512757

Genes

SERTAD4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down-regulating SERTAD4.PMID 39462261Read ↗

Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic InsightsSemantic proximity Read ↗

The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical managementSemantic proximity Read ↗

Genetic variants of the transporter SLC22A4 affect the abundance and survival of Fusobacterium nucleatum in colorectal cancer.Semantic proximity Read ↗

The Role of Fusobacterium nucleatum in Colorectal Cancer Cell Proliferation and MigrationSemantic proximity Read ↗

Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanismSemantic proximity Read ↗

Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistanceSemantic proximity Read ↗

Fusobacterium nucleatum in Colorectal Cancer: Ally Mechanism and Targeted Therapy StrategiesSemantic proximity Read ↗

Fucosyltransferases Regulated by Fusobacterium Nucleatum Promote the Progression of Colon AdenocarcinomaSemantic proximity Read ↗

Patients with mesenchymal tumours and high <i>Fusobacteriales</i> prevalence have worse prognosis in colorectal cancer (CRC)Semantic proximity Read ↗

Clinicopathological and prognostic significance of Fusobacterium nucleatum infection in colorectal cancer: a meta-analysisSemantic proximity Read ↗

Fusobacterium nucleatumSemantic proximity Read ↗

Proinflammatory and Cancer-Promoting Pathobiont Fusobacterium nucleatum Directly Targets Colorectal Cancer Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.