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Article

Systematic mutational analysis of the intracellular regions of yeast Gap1 permease.

PloS one - 19 Apr 2011

Merhi Ahmad, Gérard Nicolas, Lauwers Elsa, Prévost Martine, André Bruno

Abstract excerpt

BACKGROUND: The yeast general amino acid permease Gap1 is a convenient model for studying the intracellular trafficking of membrane proteins. Present at the plasma membrane when the nitrogen source is poor, it undergoes ubiquitin-dependent endocytosis and degradation upon addition of a good nitrogen source, e.g., ammonium. It comprises 12 transmembrane domains (TM) flanked by cytosol-facing N- and C-terminal...

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Identifiers

PMID: 21526172
DOI: 10.1371/journal.pone.0018457
PMCID: PMC3079708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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