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Article

An Oxford Nanopore Technology-Based Hepatitis B Virus Sequencing Protocol Suitable for Genomic Surveillance Within Clinical Diagnostic Settings.

International journal of molecular sciences - 31 Oct 2024

Tshiabuila Derek, Choga Wonderful, San James E, Maponga Tongai, Van Zyl Gert, Giandhari Jennifer, Pillay Sureshnee, Preiser Wolfgang, Naidoo Yeshnee, Baxter Cheryl, Martin Darren P, de Oliveira Tulio

Abstract excerpt

Chronic Hepatitis B Virus (HBV) infection remains a significant public health concern, particularly in Africa, where the burden is substantial. HBV is an enveloped virus, classified into ten phylogenetically distinct genotypes (A-J). Tests to determine HBV genotypes are based on full-genome sequencing or reverse hybridization. In practice, both approaches have limitations. Whereas diagnostic sequencing, generally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39519254
DOI: 10.3390/ijms252111702
PMCID: PMC11546910

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