Article
Nanopore sequencing from extraction-free direct PCR of dried serum spots for portable hepatitis B virus drug-resistance typing.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Aug 2020
Astbury Stuart, Costa Nunes Soares Marcia Maria, Peprah Emmanuel, King Barnabas, Jardim Ana Carolina Gomes, Shimizu Jacqueline Farinha, Jalal Paywast, Saeed Chiman H, Sabeer Furat T, Irving William L, Tarr Alexander W, McClure C Patrick
Abstract excerpt
BACKGROUND: Effective drug regimens for the treatment of hepatitis B virus (HBV) infections are essential to achieve the World Health Organisation commitment to eliminate viral hepatitis by 2030. Lamivudine (3TC) is widely used in countries with high levels of chronic HBV, however resistance has been shown to occur in up to 50 % of individuals receiving continuous monotherapy for 4 years. Telbivudine (LdT) is now...
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