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Article

Human embryonic stem cells form functional thyroid follicles.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2015

Ma Risheng, Latif Rauf, Davies Terry F

Abstract excerpt

OBJECTIVE: The molecular events that lead to human thyroid cell speciation remain incompletely characterized. It has been shown that overexpression of the regulatory transcription factors Pax8 and Nkx2-1 (ttf-1) directs murine embryonic stem (mES) cells to differentiate into thyroid follicular cells by initiating a transcriptional regulatory network. Such cells subsequently organized into three-dimensional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25585054
DOI: 10.1089/thy.2014.0537
PMCID: PMC4390159

Genes

PAX8
TPO
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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