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Article

Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo.

Frontiers in endocrinology - 1 Jan 2020

Ran Qingsong, Zhou Qiliang, Oda Kanako, Yasue Akihiro, Abe Manabu, Ye Xulu, Li Yingchun, Sasaoka Toshikuni, Sakimura Kenji, Ajioka Yoichi, Saijo Yasuo

Abstract excerpt

The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patients with hypothyroidism, but in vitro differentiation remains difficult. We earlier reported the in vivo generation of lung organs via blastocyst complementation in fibroblast growth factor 10 (Fgf10), compound, heterozygous mutant (Fgf10 Ex1mut/Ex3mut) mice. Fgf10...

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Identifiers

PMID: 33381086
DOI: 10.3389/fendo.2020.609697
PMCID: PMC7767966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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