Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

doi:10.1038/s41467-023-36922-1

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Article

Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature communications - 11 Mar 2023

Veschi Veronica, Turdo Alice, Modica Chiara, Verona Francesco, Di Franco Simone, Gaggianesi Miriam, Tirrò Elena, Di Bella Sebastiano, Iacono Melania Lo, Pantina Vincenzo Davide, Porcelli Gaetana, Mangiapane Laura Rosa, Bianca Paola, Rizzo Aroldo, Sciacca Elisabetta, Pillitteri Irene, Vella Veronica, Belfiore Antonino, Bongiorno Maria Rita, Pistone Giuseppe, Memeo Lorenzo, Colarossi Lorenzo, Giuffrida Dario, Colarossi Cristina, Vigneri Paolo, Todaro Matilde, Stassi Giorgio

Abstract excerpt

Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryonic stem cells (hESCs) with appropriate in vitro stimulation undergo sequential differentiation into thyroid progenitor cells (TPCs-day 22), which maturate into thyrocytes (day 30). Here, we create follicular...

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PMID: 36906579
DOI: 10.1038/s41467-023-36922-1
PMCID: PMC10008571

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