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Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

8 Jan 2021

Abstract excerpt

Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%. Despite causing severe disease in humans, our understanding of the host and viral determinants of CCHFV pathogenesis are limited. A major limitation in the investigation of...

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PMID: 33416494
DOI: 10.7554/elife.63906

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