Article

A missense mutation dissociates triglyceride and phospholipid transfer activities in zebrafish and human microsomal triglyceride transfer protein

2019-07-13

Abstract excerpt

<h4>SUMMARY</h4> Microsomal triglyceride transfer protein (MTP) transfers triglycerides and phospholipids and is essential for the assembly of Apolipoprotein B (ApoB)-containing lipoproteins in the endoplasmic reticulum. We have discovered a zebrafish mutant ( mttp c655 ) expressing a C-terminal missense mutation (G863V) in Mttp, one of the two subunits of MTP, that is defective at transferring triglycerides, b...

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Literature Corpus work: 9f8a9f7a-ec3f-58d5-830c-c43cb5fb03de
DOI: 10.1101/701813

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