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Article

Pancreatic cancer surveillance: Risk stratification of individuals with a germline CDKN2A pathogenic variant.

United European gastroenterology journal - 1 Dec 2024

Klatte Derk C F, Meziani Jihane, Cahen Djuna L, van Diepen Merel, Bruno Marco J, van Leerdam Monique E

Abstract excerpt

BACKGROUND: Individuals carrying a germline CDKN2A pathogenic variant (PV) are at a high risk of developing pancreatic ductal adenocarcinoma. Risk stratification could allow tailored surveillance. OBJECTIVE: To develop a Fine-Gray prediction model for the risk of PDAC in carriers of a CDKN2A PV. METHODS: Data from two large Dutch pancreatic cancer surveillance programs were used. A limited set of predictor...

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Identifiers

PMID: 39508364
DOI: 10.1002/ueg2.12662
PMCID: PMC11652335

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