Class I HLA Alleles Are Associated With an Increased Risk of Osimertinib-Induced Hypersensitivity.

doi:10.1016/j.jaip.2024.10.027

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Article

Class I HLA Alleles Are Associated With an Increased Risk of Osimertinib-Induced Hypersensitivity.

The journal of allergy and clinical immunology. In practice - 1 Jan 2025

Chen Chun-Bing, Wang Chuang-Wei, Lu Chun-Wei, Chen Wei-Ti, Zhou Bing-Rong, Chu Chia-Yu, Hsu Shang-Fu, Yang Cheng-Ta, Wen-Cheng Chang John, Yang Chan-Keng, Wang Chih-Liang, Fang Yueh-Fu, Hsu Ping-Chih, Hua Chung-Ching, Wu Chiao-En, Ko How-Wen, Chen Kun-Chieh, Yang Yi-Chien, Tseng Han-Chi, Cheng An-Yu, Tseng Li-Chuan, Shih Feng-Ya, Hung Shuen-Iu, Huang Cheng-Yang, Chung Wen-Hung

Abstract excerpt

BACKGROUND: Osimertinib, a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), shows superior lung cancer treatment efficacy. However, osimertinib-induced severe hypersensitivity, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), is frequently observed in Asian populations and hinders cancer treatment. OBJECTIVE: We investigated the genetic HLA...

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PMID: 39505105
DOI: 10.1016/j.jaip.2024.10.027

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EGFR

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