Article
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
Brain : a journal of neurology - 1 Jul 2010
Kasperaviciūte Dalia, Catarino Claudia B, Heinzen Erin L, Depondt Chantal, Cavalleri Gianpiero L, Caboclo Luis O, Tate Sarah K, Jamnadas-Khoda Jenny, Chinthapalli Krishna, Clayton Lisa M S, Shianna Kevin V, Radtke Rodney A, Mikati Mohamad A, Gallentine William B, Husain Aatif M, Alhusaini Saud, Leppert David, Middleton Lefkos T, Gibson Rachel A, Johnson Michael R, Matthews Paul M, Hosford David, Heuser Kjell, Amos Leslie, Ortega Marcos, Zumsteg Dominik, Wieser Heinz-Gregor, Steinhoff Bernhard J, Krämer Günter, Hansen Jörg, Dorn Thomas, Kantanen Anne-Mari, Gjerstad Leif, Peuralinna Terhi, Hernandez Dena G, Eriksson Kai J, Kälviäinen Reetta K, Doherty Colin P, Wood Nicholas W, Pandolfo Massimo, Duncan John S, Sander Josemir W, Delanty Norman, Goldstein David B, Sisodiya Sanjay M
Abstract excerpt
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to...
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