Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.

doi:10.1038/s41590-024-01998-4

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Article

Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.

Nature immunology - 1 Dec 2024

Walker Emma C, Javati Sarah, Todd Elizabeth M, Matlam John-Paul, Lin Xue, Bryant Michelle, Krone Emily, Ramani Rashmi, Chandra Pallavi, Green Taylor P, Anaya Edgar P, Zhou Julie Y, Alexander Katherine A, Tong R Spencer, Yuasi Lapule, Boluarte Sebastian, Yang Fan, Greenberg Lina, Nerbonne Jeanne M, Greenberg Michael J, Clemens Regina A, Philips Jennifer A, Wilson Leslie D, Halabi Carmen M, DeBosch Brian J, Blyth Christopher C, Druley Todd E, Kazura James W, Pomat William S, Morley Sharon Celeste

Abstract excerpt

Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovation in prevention and treatment. Children in Papua New Guinea (PNG) experience profound morbidity from ALRI caused by Streptococcus pneumoniae. As a result of evolutionary divergence, the human PNG population exhibits profound genetic variation and diversity. To address unmet health needs of...

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PMID: 39496954
DOI: 10.1038/s41590-024-01998-4
PMCID: PMC11908386

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COQ6

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