Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: functional implications.

Molecular biology and evolution - 1 Sept 2013

Tarazona-Santos Eduardo, Machado Moara, Magalhães Wagner C S, Chen Renee, Lyon Fernanda, Burdett Laurie, Crenshaw Andrew, Fabbri Cristina, Pereira Latife, Pinto Laelia, Redondo Rodrigo A F, Sestanovich Ben, Yeager Meredith, Chanock Stephen J

Abstract excerpt

The phagocyte NADPH oxidase catalyzes the reduction of O2 to reactive oxygen species with microbicidal activity. It is composed of two membrane-spanning subunits, gp91-phox and p22-phox (encoded by CYBB and CYBA, respectively), and three cytoplasmic subunits, p40-phox, p47-phox, and p67-phox (encoded by NCF4, NCF1, and NCF2, respectively). Mutations in any of these genes can result in chronic granulomatous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Bacterial Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black People

Share to Catalase

Share to Granulomatous Disease, Chronic

Share to Host-Pathogen Interactions

Share to NADPH Oxidase 2

Share to NADPH Oxidases

Source

Open in PubMed Open full text

Identifiers

PMID: 23821607
DOI: 10.1093/molbev/mst119
PMCID: PMC3748357

Genes

CYBA
NCF2
CYBB
NCF4
NCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: functional implications.PMID 23821607Read ↗

CYBB, an NADPH-oxidase gene: restricted diversity in humans and evidence for differential long-term purifying selection on transmembrane and cytosolic domains.Semantic proximity Read ↗

The three CYBA variants (rs4673, rs1049254 and rs1049255) are benign: new evidence from a patient with CGD.Semantic proximity Read ↗

Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations.Semantic proximity Read ↗

Hematologically important mutations: X-linked chronic granulomatous disease (third update).Semantic proximity Read ↗

CYBA encoding p22(phox), the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology.Semantic proximity Read ↗

A Founder Effect of c.257 + 2T > C Mutation in NCF2 Gene Underlies Severe Chronic Granulomatous Disease in Eleven Patients.Semantic proximity Read ↗

Novel mutations in CYBB Gene Cause X-linked chronic Granulomatous Disease in Pakistani patients.Semantic proximity Read ↗

Hematologically important mutations: The autosomal forms of chronic granulomatous disease (third update).Semantic proximity Read ↗

Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update).Semantic proximity Read ↗

Autosomal recessive chronic granulomatous disease caused by novel mutations in NCF-2, the gene encoding the p67-phox component of phagocyte NADPH oxidase.Semantic proximity Read ↗

Genetic and mutational heterogeneity of autosomal recessive chronic granulomatous disease in Tunisia.Semantic proximity Read ↗

Chronic Granulomatous Disease: Clinical and Molecular Characterization of Brazilian Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.