Genome-wide Meta-analysis for Myopic Macular Neovascularization Identified a Novel Susceptibility Locus and Revealed a Shared Genetic Susceptibility with Age-Related Macular Degeneration.

doi:10.1016/j.oret.2024.09.016

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Article

Genome-wide Meta-analysis for Myopic Macular Neovascularization Identified a Novel Susceptibility Locus and Revealed a Shared Genetic Susceptibility with Age-Related Macular Degeneration.

Ophthalmology. Retina - 1 Apr 2025

Morino Kazuya, Miyake Masahiro, Nagasaki Masao, Kawaguchi Takahisa, Numa Shogo, Mori Yuki, Yasukura Shota, Akada Masahiro, Nakao Shin-Ya, Nakata Ai, Hashimoto Hiroki, Otokozawa Ryoko, Kamoi Koju, Takahashi Hiroyuki, Tabara Yasuharu, Matsuda Fumihiko, Ohno-Matsui Kyoko, Tsujikawa Akitaka

Abstract excerpt

PURPOSE: To identify the susceptibility loci for myopic macular neovascularization (mMNV) in patients with high myopia. DESIGN: A genome-wide association study (GWAS) meta-analysis (meta-GWAS). PARTICIPANTS: We included 2783 highly myopic individuals, including 608 patients with mMNV and 2175 control participants without mMNV. METHODS: We performed a meta-analysis of 3 independent GWASs conducted according to the...

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PMID: 39489378
DOI: 10.1016/j.oret.2024.09.016

Genes

ARMS2
CETP
EGR1
TEX29
TF
ZBTB33
ZNF740

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