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Article

TNFα/TNFR1 signal induces excessive senescence of decidua stromal cells in recurrent pregnancy loss

24 Nov 2022

Abstract excerpt

Defects in decidual response are associated with adverse pregnancy outcomes which includes recurrent pregnancy loss (RPL). It is reported that cellular senescence happens during decidualization and pro-senescent decidual response in the luteal phase endometrium is related to RPL. However, the underlying mechanisms of how excessive decidual senescence takes place in RPL decidua cells remain largely unexplored. The...

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PMID: 36495656
DOI: 10.1016/j.jri.2022.103776

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