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Site-Specific Immobilization of Antibodies as a Platform Approach to Enable the Targeted Capture and Effective Removal of “Problematic” Host Cell Proteins (HCPs) from Complex Bioprocess Streams, Even at Sub-ppm Levels: Chinese Hamster Ovary (CHO) Phospholipase B-Like 2 (PLBL2)

2025-06-12

Abstract excerpt

Removal of host cell proteins (HCPs) during biotherapeutics manufacturing is vital for ensuring patient safety and biotherapeutic stability and supply. Yet, this goal remains exceptionally challenging for some HCPs. For example, phospholipase B-like 2 (PLBL2) from Chinese hamster ovary (CHO) cells (the workhorse for therapeutic protein production) plagues engineers by evading typical purification strategies. New t...

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Literature Corpus work
9e5ad7cb-8fa0-577f-9992-483d3948c934
DOI
10.22541/au.173372831.15992718/v2
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Site-Specific Immobilization of Antibodies as a Platform Approach to Enable the Targeted Capture and Effective Removal of “Problematic” Host Cell Proteins (HCPs) from Complex Bioprocess Streams, Even at Sub-ppm Levels: Chinese Hamster Ovary (CHO) Phospholipase B-Like 2 (PLBL2)DOI 10.22541/au.173372831.15992718/v2
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