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Article

Microscopic computed tomography with AI-CNN-powered image analysis: the path to phenotype bleomycin-induced lung injury.

American journal of physiology. Cell physiology - 1 Jun 2024

Henneke Ingrid, Pilz Christina, Wilhelm Jochen, Alexopoulos Ioannis, Ezaddoustdar Aysan, Mukhametshina Regina, Weissmann Norbert, Ghofrani Hossein Ardeschir, Grimminger Friedrich, Seeger Werner, Schermuly Ralph T, Wygrecka Malgorzata, Kojonazarov Baktybek

Abstract excerpt

Bleomycin (BLM)-induced lung injury in mice is a valuable model for investigating the molecular mechanisms that drive inflammation and fibrosis and for evaluating potential therapeutic approaches to treat the disease. Given high variability in the BLM model, it is critical to accurately phenotype the animals in the course of an experiment. In the present study, we aimed to demonstrate the utility of microscopic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38646782
DOI: 10.1152/ajpcell.00708.2023

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