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Article

Second Primary Cancer Risks After Breast Cancer in BRCA1 and BRCA2 Pathogenic Variant Carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2025

Allen Isaac, Hassan Hend, Walburga Yvonne, Huntley Catherine, Loong Lucy, Rahman Tameera, Allen Sophie, Garrett Alice, Torr Bethany, Bacon Andrew, Knott Craig, Jose Sophie, Vernon Sally, Lüchtenborg Margreet, Pethick Joanna, Santaniello Francesco, Goel Shilpi, Wang Ying-Wen, Lavelle Katrina, McRonald Fiona, Eccles Diana, Morris Eva, Hardy Steven, Turnbull Clare, Tischkowitz Marc, Pharoah Paul, Antoniou Antonis C

Abstract excerpt

PURPOSE: Second primary cancer (SPC) risks after breast cancer (BC) in BRCA1/BRCA2 pathogenic variant (PV) carriers are uncertain. We estimated relative and absolute risks using a novel linkage of genetic testing data to population-scale National Disease Registration Service and Hospital Episode Statistics electronic health records. METHODS: We followed 25,811 females and 480 males diagnosed with BC and tested...

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BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
England

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Neoplasms, Second Primary

Risk Assessment

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Open in PubMed Open full text

Identifiers

PMID: 39475295
DOI: 10.1200/JCO.24.01146
PMCID: PMC7616773

Genes

BRCA2
BRCA1
NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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