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Impact of BRCA1/2 pathogenic variants on ipsilateral breast tumor recurrence and prognosis following breast-conserving surgery.

Breast cancer research and treatment - 14 May 2026

Kondo Sakiko, Kida Kumiko, Suzuki Misato, Kajiura Yuka, Takei Junko, Kanomata Naoki, Yamanaka Michiko, Yoshida Atsushi

Abstract excerpt

PURPOSE: The risk of ipsilateral breast tumor recurrence (IBTR) and the prognostic outcomes of breast-conserving surgery (BCS) for germline BRCA1/2 pathogenic variant carriers (BRCA+) remain controversial. This study aimed to investigate the differences in the incidence of IBTR and prognosis between BRCA + and noncarriers (BRCA-) after BCS. METHODS: A retrospective chart review was performed in patients with...

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PMID: 42133182
DOI: 10.1007/s10549-026-07976-8

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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