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Article

Homologous recombination deficiency score is an independent prognostic factor in esophageal squamous cell carcinoma.

The journal of pathology. Clinical research - 1 Nov 2024

Wang Yulu, Ding Bowen, Tao Yunlan, Huang Lingli, Zhu Qian, Gao Chengying, Feng Mingli, Han Yuchen

Abstract excerpt

Homologous recombination deficiency (HRD) represents an impairment in the homologous recombination repair (HRR) pathway, crucial for repairing DNA double-strand breaks and contributing to genomic instability in cancer. The HRD score may be a more reliable biomarker than HRR-related gene mutations for identifying patients sensitive to poly(ADP-ribose) polymerase inhibitors. Despite its relevance in various...

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Source

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Identifiers

PMID: 39469984
DOI: 10.1002/2056-4538.70007
PMCID: PMC11519826

Genes

ABCB1
APC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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