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Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency.

Genomics, proteomics & bioinformatics - 1 Oct 2023

Li Wenbin, Gao Lin, Yi Xin, Shi Shuangfeng, Huang Jie, Shi Leming, Zhou Xiaoyan, Wu Lingying, Ying Jianming

Abstract excerpt

Defects in genes involved in the DNA damage response cause homologous recombination repair deficiency (HRD). HRD is found in a subgroup of cancer patients for several tumor types, and it has a clinical relevance to cancer prevention and therapies. Accumulating evidence has identified HRD as a biomarker for assessing the therapeutic response of tumor cells to poly(ADP-ribose) polymerase inhibitors and...

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Identifiers

PMID: 36791952
DOI: 10.1016/j.gpb.2023.02.004
PMCID: PMC10928375

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