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Article

Impact of HHIP gene polymorphisms on phenotypes, serum IL-17 and IL-18 in COPD patients of the Chinese Han population.

Respiratory research - 28 Oct 2024

Zhang Jiajun, Zhao Di, Zhang Lili, Feng Xueyan, Li Beibei, Dong Hui, Qi Yanchao, Jia Zun, Liu Fuyun, Zhao Shaohui, Zhang Jin

Abstract excerpt

BACKGROUND: Genetic factors, including the Hedgehog Interacting Protein (HHIP) gene, play a crucial role in Chronic Obstructive Pulmonary Disease (COPD) susceptibility. This study examines the association between HHIP gene polymorphisms and COPD susceptibility, phenotypes, and serum IL-17 and IL-18 levels in a Han Chinese population. METHODS: A case-control study was conducted with 300 COPD patients and 300...

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PMID: 39468530
DOI: 10.1186/s12931-024-03020-9
PMCID: PMC11520666

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