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Article

The Dopamine Transporter Is a New Target for Ischemic Stroke.

CNS neuroscience & therapeutics - 1 Oct 2024

Cheng Yan-Qiong, Zhang Ruo-Xi, Li Xing-Yuan, Zhou Xiao-Ting, Chen Ming, Liu Ai-Jun

Abstract excerpt

AIMS: Dopamine transporter (DAT) can regulate DA homeostasis and has been implicated in many nervous system diseases. Whether DAT is involved in the protection against ischemic stroke is unclear. METHODS: In vivo microdialysis measurements of DA were recorded in the ischemic penumbral area of mice with middle cerebral artery occlusion (MCAO). DAT coding gene, Slc6a3 mutation, and DAT overexpression animals were...

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Identifiers

PMID: 39467829
DOI: 10.1111/cns.70092
PMCID: PMC11518691

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