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Article

Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy.

Journal of translational medicine - 27 Oct 2024

Bertucci François, Guille Arnaud, Lerebours Florence, Ceccarelli Michele, Syed Najeeb, Adélaïde José, Finetti Pascal, Ueno Naoto T, Van Laere Steven, Viens Patrice, De Nonneville Alexandre, Goncalves Anthony, Birnbaum Daniel, Callens Céline, Bedognetti Davide, Mamessier Emilie

Abstract excerpt

BACKGROUND: Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably predicts the response to chemotherapy. Whole-exome sequencing (WES) of clinical tumor samples provides an opportunity to identify genomic alterations associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39465437
DOI: 10.1186/s12967-024-05790-8
PMCID: PMC11514970

Genes

NLRP3
PIK3CA
SLC9B1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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