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Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes

18 Dec 2020

Abstract excerpt

Characterizing key molecular and cellular pathways involved in COVID-19 is essential for disease prognosis and management. We perform shotgun transcriptome sequencing of human RNA obtained from nasopharyngeal swabs of patients with COVID-19, and identify a molecular signature associated with disease severity. Specifically, we identify globally dysregulated immune related pathways, such as cytokine-cytokine...

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PMID: 33425248
DOI: 10.1016/j.csbj.2020.12.016

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