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Article

Variants rs3804099 and rs3804100 in the TLR2 Gene Induce Different Profiles of TLR-2 Expression and Cytokines in Response to Spike of SARS-CoV-2.

International journal of molecular sciences - 15 Oct 2024

Flores-González Julio, Monroy-Rodríguez Zurisadai, Falfán-Valencia Ramcés, Buendía-Roldán Ivette, Fricke-Galindo Ingrid, Hernández-Zenteno Rafael, Herrera-Sicairos Ricardo, Chávez-Galán Leslie, Pérez-Rubio Gloria

Abstract excerpt

The present study aimed to identify in patients with severe COVID-19 and acute respiratory distress syndrome (ARDS) the association between rs3804099 and rs3804100 (TLR2) and evaluate the expression of TLR-2 on the cell surface of innate and adaptive cells of patients' carriers of C allele in at least one genetic variant. We genotyped 1018 patients with COVID-19 and ARDS. According to genotype, a subgroup of 12...

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PMID: 39456843
DOI: 10.3390/ijms252011063
PMCID: PMC11507191

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