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SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity

15 Aug 2022

Abstract excerpt

Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C and the toxic shock syndrome, together with the preferential expansion of T cells with a T-cell receptor variable β chain (TCRVβ) skewing, suggested a superantigen theory of MIS-C. For instance, recent in silico modelling evidenced...

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PMID: 36010602
DOI: 10.3390/cells11162526

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