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TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

31 May 2024

Abstract excerpt

Background In early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted. The aim of this paper was to establish whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (SP) may directly trigger NK cells and through which receptor(s). Methods SP-stimulated human NK cells have been...

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PMID: 38881905
DOI: 10.3389/fimmu.2024.1368946

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