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Article

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016

Ferraiuolo Laura, Meyer Kathrin, Sherwood Thomas W, Vick Jonathan, Likhite Shibi, Frakes Ashley, Miranda Carlos J, Braun Lyndsey, Heath Paul R, Pineda Ricardo, Beattie Christine E, Shaw Pamela J, Askwith Candice C, McTigue Dana, Kaspar Brian K

Abstract excerpt

Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) mouse oligodendrocytes induce WT motor neuron (MN) hyperexcitability and death. Moreover, we efficiently derived human oligodendrocytes from a large number of controls and patients with sporadic and familial ALS, using two different...

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Identifiers

PMID: 27688759
DOI: 10.1073/pnas.1607496113
PMCID: PMC5081600

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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