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Article

Hypomyelinated vps16 Mutant Zebrafish Exhibit Systemic and Neurodevelopmental Pathologies.

International journal of molecular sciences - 1 Jul 2024

Banerjee Shreya, Bongu Shivani, Hughes Sydney P, Gaboury Emma K, Carver Chelsea E, Luo Xixia, Bessert Denise A, Thummel Ryan

Abstract excerpt

Homotypic Fusion and Protein Sorting (HOPS) and Class C-core Vacuole/Endosome Tethering (CORVET) complexes regulate the correct fusion of endolysosomal bodies. Mutations in core proteins (VPS11, VPS16, VPS18, and VPS33) have been linked with multiple neurological disorders, including mucopolysaccharidosis (MPS), genetic leukoencephalopathy (gLE), and dystonia. Mutations in human Vacuolar Protein Sorting 16...

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Identifiers

PMID: 39000367
DOI: 10.3390/ijms25137260
PMCID: PMC11242861

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