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Article

Distinct HLA associations of LGI1 and CASPR2-antibody diseases.

Brain : a journal of neurology - 1 Aug 2018

Binks Sophie, Varley James, Lee Wanseon, Makuch Mateusz, Elliott Katherine, Gelfand Jeffrey M, Jacob Saiju, Leite M Isabel, Maddison Paul, Chen Mian, Geschwind Michael D, Grant Eleanor, Sen Arjune, Waters Patrick, McCormack Mark, Cavalleri Gianpiero L, Barnardo Martin, Knight Julian C, Irani Sarosh R

Abstract excerpt

The recent biochemical distinction between antibodies against leucine-rich, glioma-inactivated-1 (LGI1), contactin-associated protein-2 (CASPR2) and intracellular epitopes of voltage-gated potassium-channels (VGKCs) demands aetiological explanations. Given established associations between human leucocyte antigen (HLA) alleles and adverse drug reactions, and our clinical observation of frequent adverse drugs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29788256
DOI: 10.1093/brain/awy109
PMCID: PMC6118231

Genes

LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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