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Clonal hematopoiesis in LGI1-antibody encephalitis.

Annals of clinical and translational neurology - 1 Oct 2024

Shin Soo Jean, Jang Yoonhyuk, Ahn Soo Hyun, Mon Su Yee, You Ji Hye, An Hong Yul, Sun Choong Hyun, Koh Youngil, Chu Kon, Lee Sang Kun, Lee Soon-Tae

Abstract excerpt

OBJECTIVE: Leucine-rich glioma-inactivated 1 (LGI1)-antibody encephalitis (LGI1e), the major form of autoimmune encephalitis (AE) presented with memory loss and faciobrachial dystonic seizure, commonly develops in aged population. Hematologic aging is often accompanied by clonal hematopoiesis (CH), a phenomenon in which specific mutations accumulate, potentially leading to autoimmune disorders or malignancies....

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Autoantibodies
Clonal Hematopoiesis
Encephalitis
Mutation
Repressor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Signaling Peptides and Proteins

Aged, 80 and over

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Open in PubMed Open full text

Identifiers

PMID: 39199016
DOI: 10.1002/acn3.52192
PMCID: PMC11514903

Genes

ASXL1
LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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