Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancing the Cytotoxicity and Apoptotic Efficacy of Parasporin-2-Derived Variants (Mpp46Aa1) on Cancer Cell Lines.

Toxins - 25 Sept 2024

Alarcón-Aldana Juan S, Visser Lydia, Rueda-Forero Nohora J, Pinzón-Reyes Efraín H, Rondón-Villarreal Paola, Suárez-Barrera Miguel O

Abstract excerpt

Parasporin PS2Aa1, recently renamed Mpp46Aa1, is an anti-cancer protein known for its selectivity against various human cancer cell lines. We genetically modified native PS2Aa1 to create a library of approximately 100 mutants. From this library, we selected promising mutants based on their half-maximal inhibitory concentration (IC50) and sequence variations. In this study, Variant 3-35, with the G257V...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Molecular Dynamics Simulation

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39453191
DOI: 10.3390/toxins16100415
PMCID: PMC11511244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancing the Cytotoxicity and Apoptotic Efficacy of Parasporin-2-Derived Variants (Mpp46Aa1) on Cancer Cell Lines.PMID 39453191Read ↗

Design of human granzyme B variants resistant to serpin B9.Semantic proximity Read ↗

Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions.Semantic proximity Read ↗

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signalingSemantic proximity Read ↗

Cordycepin derived from engineered Pichia pastoris inhibits fibrosarcoma HT1080 cells by targeting Akt1 and kinase activitySemantic proximity Read ↗

Enhancement of antitumor response of staphylococcal enterotoxin C2 mutant 2M-118 by promoting cell-mediated antitumor immunity.Semantic proximity Read ↗

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.Semantic proximity Read ↗

Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.Semantic proximity Read ↗

Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells.Semantic proximity Read ↗

Screening, purification, and identification of annexin B1 mutants with high phosphatidylserine-binding activity and reduced immunogenicity.Semantic proximity Read ↗

Mutational Analysis of RIP Type I Dianthin-30 Suggests a Role for Arg24 in Endocytosis.Semantic proximity Read ↗

Antitumor Effects of a Peptide Sequences Based on Gramicidin Molecule as Possible Inhibitor of PD-1 and PD-L-1Semantic proximity Read ↗

Discovery of human-like L-asparaginases with potential clinical use by directed evolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.