Article

Cordycepin derived from engineered Pichia pastoris inhibits fibrosarcoma HT1080 cells by targeting Akt1 and kinase activity

2025-01-17

Abstract excerpt

Fibrosarcoma cells exhibit low sensitivity to chemotherapy and significant drug resistance, emphasizing the urgent need for effective, low-toxicity therapeutic agents with reliable production methods and novel treatment strategies. Cordycepin (3’-deoxyadenosine) has shown promising therapeutic potential in cancer treatment. In this study, cordycepin was produced using a genetically engineered Pichia pastoris stra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0eccc5a-f2a0-552d-8744-8b4f920d4615
DOI: 10.22541/au.173710998.89396227/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cordycepin derived from engineered Pichia pastoris inhibits fibrosarcoma HT1080 cells by targeting Akt1 and kinase activityDOI 10.22541/au.173710998.89396227/v1Read

Application and research progress of cordycepin in the treatment of tumours (Review)Semantic proximity Read

Improvement of cordycepin production by an isolated Paecilomyces hepiali mutant from combinatorial mutation breeding and medium screening.Semantic proximity Read

Cordycepin Downregulates Cdk-2 to Interfere with Cell Cycle and Increases Apoptosis by Generating ROS in Cervical Cancer Cells: in vitro and in silico StudySemantic proximity Read

Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cellsSemantic proximity Read

Molecular screening for nigericin treatment in pancreatic cancer by high-throughput RNA sequencingSemantic proximity Read

The response of PIK3CA/KRAS-mutant colorectal cancer stem-like cells to RGD-peptide FraC produced by the strawberry anemone: A promising water-soluble peptide-based inhibitor of metastasis-driver gene CXCR4, stem cell regulatory genes and self-renewal.Semantic proximity Read

Enhanced Cordycepin Production in Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Mutated by a Multifunctional Plasma Mutagenesis System.Semantic proximity Read

Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive reviewSemantic proximity Read

Annexin-directed β-glucuronidase for the targeted treatment of solid tumors.Semantic proximity Read

Identification of cordycepin biosynthesis-related genes through de novo transcriptome assembly and analysis in Cordyceps cicadaeSemantic proximity Read

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cellsSemantic proximity Read

Cordycepin Inhibits Growth and Metastasis Formation of MDA-MB-231 Xenografts in Nude Mice by Modulating the Hedgehog PathwaySemantic proximity Read