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Article

Pathway enrichment in genome-wide analysis of longitudinal Alzheimer's disease biomarker endophenotypes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2024

Rosewood Thea J, Nho Kwangsik, Risacher Shannon L, Liu Shiwei, Gao Sujuan, Shen Li, Foroud Tatiana, Saykin Andrew J

Abstract excerpt

INTRODUCTION: The genetic pathways that influence longitudinal heterogeneous changes in Alzheimer's disease (AD) may provide insight into disease mechanisms and potential therapeutic targets. METHODS: Longitudinal endophenotypes from the Alzheimer's Disease Neuroimaging Initiative (ADNI) representing amyloid, tau, neurodegeneration (A/T/N), and cognition were selected. Genome-wide association analysis was...

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Identifiers

PMID: 39440837
DOI: 10.1002/alz.14308
PMCID: PMC11667536

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