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Article

A Novel A105Y Mutant of CYP17A1 Exhibits Almost Perfect Regioselectivity in the Production of 17α-Hydroxyprogesterone.

Journal of agricultural and food chemistry - 6 Nov 2024

Du Yuyao, Tian Huan, Li Jie, Gao Jikai, Liu Weidong, Lu Fuping, Qin Hui-Min, Mao Shuhong

Abstract excerpt

17α-Hydroxyprogesterone (17α-OHP) is a steroid hormone with significant biological activity that can be obtained by catalyzing progesterone (PROG), the main product of sitosterol, through CYP17A1. However, increasing the catalytic specificity of HCYP17A1 for C17 hydroxylation of progesterone (PROG) poses a formidable challenge due to the close proximity of the C16 and C17 positions. In this study, a rational...

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PMID: 39440611
DOI: 10.1021/acs.jafc.4c05982

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