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Article

Structures of human steroidogenic cytochrome P450 17A1 with substrates.

The Journal of biological chemistry - 21 Nov 2014

Petrunak Elyse M, DeVore Natasha M, Porubsky Patrick R, Scott Emily E

Abstract excerpt

The human cytochrome P450 17A1 (CYP17A1) enzyme operates at a key juncture of human steroidogenesis, controlling the levels of mineralocorticoids influencing blood pressure, glucocorticoids involved in immune and stress responses, and androgens and estrogens involved in development and homeostasis of reproductive tissues. Understanding CYP17A1 multifunctional biochemistry is thus integral to treating prostate and...

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Identifiers

PMID: 25301938
DOI: 10.1074/jbc.M114.610998
PMCID: PMC4239641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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