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Identification of drug resistance-related virulence gene mutations in 667 clinical Mycobacterium tuberculosis isolates.

Journal of infection in developing countries - 30 Sept 2024

Zhang Yu, Chen Xinchang, Wang Shiyong, Jiang Ning, Shao Lingyun, Chen Jiazhen

Abstract excerpt

INTRODUCTION: Drug-resistant tuberculosis is a severe global public health threat. Virulence factors and antibiotic resistance are generally considered to play a significant role in bacterial pathogenesis. However, the interaction between resistance and virulence in Mycobacterium tuberculosis (MTB) remains unclear. METHODOLOGY: Here, we used whole genome sequences from 667 MTB isolates from 14 countries to...

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PMID: 39436849
DOI: 10.3855/jidc.18081

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