Article

Altered Glutamate Homeostasis in Paramagnetic Rim Lesions of Patients with Multiple Sclerosis

2026-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Paramagnetic rim lesions are a subset of focal white matter lesions specific to multiple sclerosis that are chronically inflamed and are associated with increased tissue injury, brain atrophy, and clinical disability. The molecular mechanisms linking paramagnetic rim lesions to these progressive biological outcomes remain unclear. Glutamatergic dysregulation has been hypothesized as a mechanism...

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Literature Corpus work: 56af3cdc-057d-56f1-93e0-1b711ebef377
DOI: 10.64898/2026.08.06.26359875

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