Article
DNA methylation analysis to differentiate reference, breed, and parent-of-origin effects in the bovine pangenome era.
GigaScience - 2 Jan 2024
MacPhillamy Callum, Chen Tong, Hiendleder Stefan, Williams John L, Alinejad-Rokny Hamid, Low Wai Yee
Abstract excerpt
BACKGROUND: Most DNA methylation studies have used a single reference genome with little attention paid to the bias introduced due to the reference chosen. Reference genome artifacts and genetic variation, including single nucleotide polymorphisms (SNPs) and structural variants (SVs), can lead to differences in methylation sites (CpGs) between individuals of the same species. We analyzed whole-genome bisulfite...
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