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Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells

26 Sept 2024

Abstract excerpt

The etiology of inflammatory bowel disease (IBD) is complex, with much room for a greater understanding and development of improved therapies. Therefore, establishing a reliable IBD model is crucial for future advancements. In this study, human induced pluripotent stem (iPS) cell-derived colon organoids (hiPSC-COs) were treated with a combination of tumor necrosis factor alpha (TNF-α), interferon-gamma (IFN-γ),...

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PMID: 39435148
DOI: 10.1016/j.isci.2024.111049

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