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Patient-derived organoids for therapy personalization in inflammatory bowel diseases

24 Jun 2022

Abstract excerpt

cell structures derived from stem cells that can self-organize into functional organ-specific structures. Organoids may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic profile. These models are powerful pharmacological tools to better understand IBD pathogenesis, to study the mechanisms of action on the...

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PMID: 35979165
DOI: 10.3748/wjg.v28.i24.2636

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