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Article

Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior.

Communications biology - 21 Oct 2024

Sullivan Kyle A, Lane Matthew, Cashman Mikaela, Miller J Izaak, Pavicic Mirko, Walker Angelica M, Cliff Ashley, Romero Jonathon, Qin Xuejun, Mullins Niamh, Docherty Anna, Coon Hilary, Ruderfer Douglas M, Garvin Michael R, Pestian John P, Ashley-Koch Allison E, Beckham Jean C, McMahon Benjamin, Oslin David W, Kimbrel Nathan A, Jacobson Daniel A, Kainer David

Abstract excerpt

Genome-wide association studies (GWAS) identify genetic variants underlying complex traits but are limited by stringent genome-wide significance thresholds. We present GRIN (Gene set Refinement through Interacting Networks), which increases confidence in the expanded gene set by retaining genes strongly connected by biological networks when GWAS thresholds are relaxed. GRIN was validated on both simulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39433874
DOI: 10.1038/s42003-024-06943-7
PMCID: PMC11494055

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