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Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action

28 Aug 2004

Abstract excerpt

Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found in particular in syncytiotrophoblast. After transfection into various cell types it has proven to be a very fusogenic protein, inducing the formation of syncytia. Therefore, the question rises as to whether syncytin...

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PMID: 15333590
DOI: 10.1093/humupd/dmh039

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